The prevalence of recurrent cystitis history in patients with IC/Bladder Pain Syndrome
IUGA Academy. Seo Son H. Jun 30, 2018; 213070; 359 Topic: Pelvic Pain
Dr. Hee Seo Son
Dr. Hee Seo Son

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The prevalance of recurrent cystitis history in patients with IC/bladder pain syndrome

Son, HS1; Kim, JH1

1: Yonsei University College of Medicine

Introduction: Recurrent cystitis and interstitial cystitis/bladder pain syndrome (IC/BPS) are fairly different disease entities. Whereas recurrent cystitis has evidence of infection without bladder pain, interstitial cystitis is associated with pain on bladder distension without evidence of urinary tract infection. However, these two contrasting diseases have some concomitant features in their hypothetical etiology. Although the pathophysiology is not clear until now, recurrent cystitis and interstitial cystitis are believed to be associated with compromised urothelium, inflammation, immune system, and abnormal response of nervous system. Moreover, the chronicity and absence of curative treatment of the two diseases render the physicians and patients in hardship.

Objective: To evaluate the relevance between IC/BPS and recurrent cystitis, we performed initial patient survey with IC/BPS patients regarding the recurrent cystitis episode

Methods: Female patients diagnosed with IC/BPS who received endoscopic treatment from January 2013 to January 2018 were surveyed. All the patients satisfied diagnosis criteria of National Institute of Diabetes and Digestive and Kidney Diseases and all of them had cystoscopically proven Hunner’s lesion. Recurrent cystitis was defined as repetitive advent of lower urinary tract symptom accompanying dysuria, frequency with or without urgency showing resolution after antibiotics treatment and then followed by similar episode in frequency more than three times a year.

Results: A total of 44 female patients were investigated. Mean age at diagnosis as IC/BPS was 65.5 years old (36.5-82.2). Out of them, 23 (52.3 %) patients had previous history of recurrent cystitis persisted several years before advent of bladder pain, and 6 (13.6 %) patients had previous history of treatment for dysuria and urinary frequency, however the information about the medication and symptom periods could not be assessed exactly. The other 15 (34.1 %) patients had not experienced recurrent cystitis before diagnosis of IC/BPS.

Conclusions: Even though these results are insufficient to announce evidence based relation between recurrent cystitis and interstitial cystitis, our preliminary survey showed a probability that repetitive assault of bacterial cystitis, resultant remodeled urothelium and nerve inflammation might predispose the interstitial cystitis in one linear pathogenic course. Our additional research in clinical and basic fields is going to be followed trying to identify pathophysiology and find out treatment target of two intractable urological problems

Figure 1. Distribution of patients grouped by treatment history before diagnosis with IC/BPS


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